Pharmaceutical composition containing a hemoglobin based Oxygen carrier for Targeting of Cancer Treatment and preventing the repetition of the same method
NORMAN FUNG MAN WAI,SZE HANG LAU,SUI YI KWOK,BING LOU WONG
申请号：
ARP130103741
公开号：
AR093023A1
申请日:
2013.10.15
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Claim 1: pharmaceutical composition that contains a carrier of Oxygen to hemoglobin for the targeting of Cancer Treatment and Prevention of recurrence of the same.Characterized in that is configured to contact a receptor expressed on the surface of cancer cells within a mass of cancerous tissue or tumor so that the hemoglobin based Oxygen carrier in Pharmaceutical triggers a mechanism mediated by Recep Tor to facilitate the uptake and Localization of the hemoglobin based Oxygen carrier in LAs cancer cells within the mass of tumor tissues or cells for the Induction of apoptosis in the cells of these tissues and cancerous Tumors, including self-renewal of cells and to prevent cancer recurrence tumor initiating, providing Oxidative stress or shock to these tissues or tumors.And sensitize cancerous tissues or tumors to chemotherapeutic agent or radiotherapy at the same time or later.Claim 2: the pharmaceutical Composition of claim 1, characterized in that it comprises Furthermore a chemotherapeutic Agent is chemically conjugated to the hemoglobin based Oxygen carrier for orientation synergistically tissues or tumors Inc This includes Self Renewable cells and Tumor initiating cells.Claim 3: the pharmaceutical Composition of claim 1, wherein Said chemotherapeutic Agent is selected from bortezomib, 5-fluorouracil, doxorubicin, cisplatin, or any combination thereof.The pharmaceutical Composition of claim 4: claim 1, wherein said in hemoglobin based Oxygen Carrier is selected from a Heat Stable tetrameric hemoglobin cross-linked hemoglobin level, or a Polymerized hemoglobin Molecule modif Built with an undetectable amount of dimer concentration and low concentration of methemoglobin.Reivindicación 1: Composición farmacéutica que contiene un portador de oxígeno a base de hemoglobina para la focalización del tratamiento del cáncer y prevención de repetición del mismo, caracterizado porque es configurado para dirigirse a un receptor expresado en la superficie de las células can
