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METHODS FOR PREPARATION OF LIPID-ENCAPSULATED THERAPEUTIC AGENTS
专利权人:
Norbert Maurer;Pieter R. Cullis;Kim F. Wong
发明人:
Norbert Maurer,Kim F. Wong,Pieter R. Cullis
申请号:
US13372285
公开号:
US20120276207A1
申请日:
2012.02.13
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Fully lipid-encapsulated therapeutic agent particles of a charged therapeutic agent are prepared by combining a lipid composition containing preformed lipid vesicles, a charged therapeutic agent, and a destabilizing agent to form a mixture of preformed vesicles and therapeutic agent in a destabilizing solvent. The destabilizing solvent is effective to destabilize the membrane of the preformed lipid vesicles without disrupting the vesicles. The resulting mixture is incubated for a period of time sufficient to allow the encapsulation of the therapeutic agent within the preformed lipid vesicles. The destabilizing agent is then removed to yield fully lipid-encapsulated therapeutic agent particles. The preformed lipid vesicles comprise a charged lipid which has a charge which is opposite to the charge of the charged therapeutic agent and a modified lipid having a steric barrier moiety for control of aggregation.
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