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Process for the preparation of galanthamine hydrobromide
专利权人:
Indena S.p.A.
发明人:
Gabetta, Bruno,Mercalli, Enrico
申请号:
AU2005315960
公开号:
AU2005315960B2
申请日:
2005.11.23
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
A process for the purification of galanthamine (I) comprising precipitationof galanthamine hydrobromide from a mixture of alkaloids obtained from a plantof the family containing galanthamine, treatment ofthe hydrobromide with alkali, extraction and crystallization of galanthaminewith a solvent of general formula (II), in which R is hydrogen or methyland R is selected from -butyl, isobutyl, -butyland -butyl. The resulting pure galanthamine can be conveniently usedfor the preparation of galanthamine hydrobromide.
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