CRISTAL DE LÉONURINE ET SON UTILISATION DANS LA PRÉPARATION DE SENSIBILISATEUR À L'INSULINE, DE MÉDICAMENT HYPOGLYCÉMIANT ET DE MÉDICAMENT DE RÉDUCTION DES LIPIDES
Zhuhai Hengqin New District Zhongzhu Zhengtai Medical Management Co. Ltd.
发明人:
申请号：
EP18870310.2
公开号：
EP3685834A1
申请日:
2018.09.18
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
This invention belongs to the modern pharmaceutical field of Traditional Chinese Medicine, and relates to an herbal extract of Chinese Motherwort and its application in pharmacy, which specifically relates to the crystal structure of a Chinese Motherwort extract: Leonurine, and its application in the preparation of medicine. The chemical name of the above-mentioned Leonurine is 4-guanidino-1-)butyl 4-hydroxy-3,5-dimethoxybenzoate. The invention by specific methods prepares leonurine as 6 kinds of crystals with different crystal forms. Specifically, there are six different structures of leonurine sulfate crystals, two of them are hydrate, two are anhydrous crystal form, one is methanol solvate, one is ethanol solvate. The leonurine crystal forms of this invention can applicate in preparing medicine such as insulin sensitizer, hypoglycemic and lipid-lowering drugs. The above mentioned insulin sensitizers are particularly useful in treating insulin resistance syndrome, and the above mentioned lipid-lowering drugs are useful in the treatment of disorders of lipid metabolism, hyperlipidemia and their complications.
