(57)< Abstract > This invention offers the imitation body of natural kahararido. The aforementioned chemical compound is good differing at the time of the amino acid of one or more, and constituting of the acyl side chain of one or more. Appropriately, as for the imitation body of this invention, in order to distinguish with kahararido which exists naturally becomes the cause, it possesses at least one of feature below: From the (1)1 3, from especially 1 or 2, most especially from 7 and especially 1 the amino acid which is not the same as the amino acid of the chemical compound which becomes, the cause of 1 From the (2)1 from 10 and especially 1 6, from 3, most especially especially from 1, the addition methylene basis in the side chain acyl basis of the chemical compound which becomes, the cause of 1 or 2 From the (3)1 from 10 and especially 1 6, from 3, most especially especially from 1 the methylene basis which is abbreviated from the side chain acyl basis of the chemical compound which becomes, the cause of 1 or 2 From the (4)1 3, from especially it was added to the side chain acyl basis of the chemical compound which becomes, the cause of 1 or 3 from 6 and especially 1 or the substituent which is abbreviated from the aforementioned acyl basis.本発明は、天然カハラリドの模倣体を提供する。前記化合物は、一つ以上のアミノ酸、及び一つ以上のアシル側鎖の構成において異なっても良い。適切には、本発明の模倣体は、元となる天然に存在するカハラリドと区別するために、以下の特徴の少なくとも一つを有する:(1)1から7、特に1から3、より特には1または2、最も特には1の、元となる化合物のアミノ酸と同じではないアミノ酸(2)1から10、特に1から6、より特には1から3、最も特には1または2の、元となる化合物の側鎖アシル基における付加的なメチレン基(3)1から10、特に1から6、より特には1から3、最も特には1または2の、元となる化合物の側鎖アシル基から省略されたメチレン基(4)1から6、特に1から3、より特には1または3の、元となる化合物の側鎖アシル基に付加されたまたは前記アシル基から省略された置換基。
