The present invention relates generally to methods and related kit to maximize the effectiveness of anti-fungus medicines including Vicks Vapor Rub and to mitigate the spread of infection to other toes or fingers and to other people. The kit consists of part of disposable nitrile glove or the like, anti-fungus medicine such as topical drug, and a tape. Barrier-inverting method and rolling-up method have been disclosed on how to apply the kit to the infected areas.