PROBLEM TO BE SOLVED: To provide human variable chain framework regions and a humanized antibodies comprising the framework regions, the antibodies being specific for integrin β1, and to provide methods for utilizing the antibodies to treat diseases such as cancer.SOLUTION: Provided is a humanized antibody which comprises a heavy chain variable (VH) region and a light chain variable (VL) region, and specifically binds to integrin β1, the VH region having less than about 97% identity to a VH region having a particular amino acid sequence, and the VL region having less than about 97% identity to a VL region having another specific amino acid sequence.SELECTED DRAWING: NoneCOPYRIGHT: (C)2019,JPO&INPIT【課題】ヒト可変鎖フレームワーク領域及び前記フレームワーク領域を含むインテグリンβ１に特異的なヒト化抗体、および、癌のような疾患を治療するために前記抗体を利用するための方法の提供。【解決手段】重鎖可変（ＶＨ）領域と軽鎖可変（ＶＬ）領域を含み、インテグリンβ１に特異的に結合するヒト化抗体であって、前記ＶＨ領域が特定のアミノ酸配列を有するＶＨ領域に対して約９７％未満の同一性を有し、かつ、前記ＶＬ領域が別の特定のアミノ酸配列を有するＶＬ領域に対して約９７％未満の同一性を有する、ヒト化抗体。【選択図】なし
