The present invention relates to an oral instant soluble film former of Olanzapine, its preparation, and pharmaceutical use thereof. The aforesaid film former include the following weight percentage composition: olanzapine: 1 to 30%, a polymer film-formingmaterial: 40% to 90%, a plasticizer: 0 to 40%, a flavoring agent: 0 to 30%, other excipients: 0 to 5%. This formulation can be administered without water delivery service, rapidly melted in the mouth, which can prevent patients from hiding the drug in the mouth and spitting the drug out, and help improve medication compliance. The main drug of the dosage form obtained by the preparation of this present invention are well dispersed, the appearance of the finished product is good, the main drug has rapid dissolution rate and good stability, the dose of product is accurate, and there is almost not dust in the production process which can sole the problems including labor protection and environmental pollution.本發明涉及一種奧氮平口腔速溶膜劑、其製備方法及醫藥用途,該膜劑包括如下重量百分比的組分:奧氮平1至30wt%,高分子成膜材料:40至90wt%,增塑劑:0至40wt%,矯味劑0至30wt%,其他輔料:0至5wt%。該種劑型給藥不需用水送服,能在口腔中快速融化、避免精神分裂症患者在口腔中藏藥及吐藥的現象,有助於提高患者用藥依從性。用本發明的製備方法所獲得劑型主藥在親水性基質膠液中的分散效果以及成品外觀良好,主藥溶出迅速、穩定性好,且產品劑量準確,在生產過程中幾乎無粉塵飛揚,可解決勞動保護和環境污染問題。
