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5,6-disubstituted oxindole derivatives and their use for the preparation of a medicine for the treatment of vasopressin-dependent diseases
专利权人:
ABBOTT GMBH & CO. KG;ABBVIE DEUTSCHLAND GMBH & CO KG
发明人:
BRAJE, WILFRIED,OOST, THORSTEN,NETZ, ASTRID,WERNET, WOLFGANG,UNGER, LILIANE,HORNBERGER, WILFRIED,LUBISCH, WILFRIED
申请号:
ES08857372
公开号:
ES2455197T3
申请日:
2008.12.05
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Compounds of formula I.A ** Formula ** in which R 1 represents hydrogen, methoxy or trifluoromethoxy; R2 represents hydrogen or methoxy; R3 represents hydrogen or C1-C4 alkyl; R4 represents fluorinated ethoxy or ethoxy; R5 represents hydrogen; R8 represents Br, Cl, F or CN; R7 represents Cl or F; X1 represents O, NH or CH2; X2 and X3 represent N or CH, with the proviso that X2 and X3 do not represent N at the same time; and X4 represents N or CH; as well as pharmaceutically acceptable salts thereof.Compuestos de fórmula I.A**Fórmula** en la que R1 representa hidrógeno, metoxilo o trifluorometoxilo; R2 representa hidrógeno o metoxilo; R3 representa hidrógeno o alquilo C1-C4; R4 representa etoxilo o etoxilo fluorado; R5 representa hidrógeno; R8 representa Br, Cl, F o CN; R7 representa Cl o F; X1 representa O, NH o CH2; X2 y X3 representan N o CH, con la condición de que X2 y X3 no representen N al mismo tiempo; y X4 representa N o CH; así como sales farmacéuticamente aceptables de los mismos.
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