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COMPOSES HETEROBICYCLIQUES COMME INHIBITEURS DE KINASE
专利权人:
TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人:
OGURO, YUYA,IMAMURA, SHINICHI,CARY, DOUGLAS R.,OKANIWA, MASANORI
申请号:
CA2689514
公开号:
CA2689514C
申请日:
2008.06.04
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
A compound representedby the formula (I): wherein Z1, 4,Z3 and Z4 are the following combination,(Z1,Z2,Z3,Z4)=(CR4,N,CR5,C),(N,N,CR5,C), (N,C,CR5,N), (S,C,CR5,C)or (S,C,N,C); R1 and R2 are the same ordifferent and each is (1) a hydrogen atom,(2) a halogen atom, (3) a group bondedvia a carbon atom, (4) a group bonded viaa nitrogen atom, (5) a group bonded viaan oxygen atom or (6) a group bonded viaa sulfur atom; R3 is an amino optionallyhaving substituent(s); R4 and R5 are thesame or different and each is (1) a hydrogen atom, (2) a halogen atom, (3) agroup bonded via a carbon atom, (4) a group bondedvia a nitrogen atom, (5) a group bonded via an oxygen atom or (6) a groupbonded via a sulfur atom; R3 and R4 optionally form aring optionally having substituent(s); and a group represented by the formula(A) is a cyclic group optionally having substituent(s),or a salt thereof.
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