Jon R. Lorsch,Julie Ellen Takacs,Timothy Brian Neary
申请号：
US13051610
公开号：
US08828976B2
申请日:
2011.03.18
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A screening method for identifying compounds that alter the fidelity with which the initiation codon in mRNAs is recognized by the translational apparatus in eukaryotes is disclosed. This screening method was used to identify compounds having such activity. Methods of altering the fidelity of initiation codon selection are also disclosed. Methods of treating disorders characterized by single nucleotide mutations in initiation codons using compounds identified by the screening method, as well as methods of treating fungal and parasitic infections and hyperproliferative disorders using compounds identified by the screening method are also disclosed.
