Vessel wound closure systems and method for sealing a puncture wound in a targetvessel, such as those puncture wounds that occur from interventional procedures.The vessel wound closure system generally comprises an introducer (10) and ahydratable hemostatic membrane (30) dislodgable from over a portion of the introducerto seal a vessel wound upon hydration of the membrane. The membrane may includea glaze on an outside surface thereof to help contorl hydration of the membrane.