KEWALRAMANI RAJ,PATEL RAKESH,RUDDY STEPHEN B,BULLOCK JOHN,MCGURK SIMON L
申请号：
NZ70189810
公开号：
NZ701898A
申请日:
2010.04.08
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is a multiparticulate composition comprising a plurality of beads, each bead comprising: an inert substrate or core a solubilizing agent in the form of a surface active agent or a pH modulator disposed about the inert substrate or between the semi-permeable layer and the medicament layer, a semipermeable coating particles of a medicament said particles having an effective average particle size of less than or about 2 &mum and a surface stabilizer adsorbed on the surface of the medicament particles. Further disclosed are the methods for making composition in the form of a multiparticulate dosage form, comprising: contacting particles of medicament with at least one surface stabilizer for a time and under conditions sufficient to provide medicament particles having an effective average particle size of less than or about 2 &mum and forming a plurality of beads, each bead comprising: an inert core a layer of solubilizing agent a layer of the medicament particles and a semipermeable coating as the outermost layer.
