MODIFIED AAV CONSTRUCTS AND USES THEREOF

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专利权人:

UNIVERSITY OF MASSACHUSETTS

发明人:

GAO, GUANGPING,XIE, JUN,ZAMORE, PHILLIP D.

申请号：

CA3021949

公开号：

CA3021949A1

申请日:

2016.04.15

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The present disclosure relates to the field of rAAV delivery of transgenes. In some aspects, the disclosure relates to RNAi. Provided herein are recombinant adeno-associated virus (rAAV) vectors comprising modified ITRs. In some embodiments, the modified ITRs comprise a sequence encoding a shRNA, miRNA, or AmiRNA.

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