SEPULVEDA REYES, JUVENAL ANTONIO,BERRIOS CORNEJO, MIRIAM ROSA,FUENZALIDA DIAZ, MIGUEL ANGEL,MARKOVITS ROJAS, ALEJANDRO,HARTING GLADE, THOMAS FRANCIS
申请号：
CA2822314
公开号：
CA2822314A1
申请日:
2011.12.25
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
A simple, efficient method for obtaining a concentrate that comprises around 80% by weight ?-3 fatty acid ethyl esters from a composition of material that contains ?-3 fatty acid esters or free ?-3 fatty acids, which comprises the following steps: a) placing the composition of material in contact with at least 96% by weight ethanol an alkali and metal hydroxide at a temperature between 60 and 200°C to form a liquid mixture that comprises fatty acid alkaline salts； b) cooling the liquid mixture to a temperature between 50 and -20°C to form a solid phase and a liquid phase, and separating the liquid phase from the solid phase； c) placing the liquid phase separated in step b) in contact with an acid to form an acidified mixture with a water content of less than 10%, in which the mixture consists of a solid phase that comprises the alkali metal salt of the acid and a liquid phase that comprises ?-3 fatty acids； d) heating the mixture from step c) to 50 to 150°C in the presence of an esterification catalyst to form a mixture that comprises ?-3 fatty acid ethyl esters； e) placing the mixture from step d) in contact with an alkali to form a neutralized mixture； f) distilling the neutralized mixture to obtain a distillate that comprises around 80% by weight ?-3 fatty acid ethyl esters.
