The invention relates to oligonucleosides having alternating segments of sugar-modified nucleosides and 2~-deoxynucleosides, and uses thereof. The inventionfurther relates to oligonucleotides having alternating segments of sugar-modified nucleotides and 2~-deoxynucleotides, and uses thereof. Such usesinclude the preparation of antisense oligonucleotides and their use for theprevention or depletion of function of a target nucleic acid of interest, suchas an RNA, in a system. Accordingly, an oligonucleotide of the invention isuseful for therapeutic, analytical and diagnostic methods and uses, as well asa component of compositions and commercial packages corresponding to suchmethods and uses.
