A radiological imaging apparatus (10) acquires a radiological brain image of a subject after administration of a radio tracer binding to a target substance indicative of a clinical pathology. In one embodiment, the clinical pathology is amyloid deposits in the brain at a level correlative with Alzheimers disease and the target substance is amyloid deposits. A processor (C) tests for the clinical pathology by: performing non-rigid registration of the brain image with a positive template (32P) indicative of having the clinical pathology and with a negative template (32N) indicative of not having the clinical pathology generating positive and negative result metrics (36P, 36N) quantifying closeness of the registration with the positive and negative template respectively and generating a test result (54) based on the positive result metric and the negative result metric. An independent test result is generated by quantifying a second mode of an intensity histogram for the brain image.
