A surgical instrument includes an insertion section, a first jaw and a second jaw installed at a distal end portion of the insertion section and having a predetermined curved shape, a suture unit, a guide section disposed in at least one of the first jaw and the second jaw, an actuation section having a shaft body movably guided by the guide section and a blade section disposed at a position apart from the shaft body in a direction crossing a direction in which a centerline of the shaft body extends and connected to the shaft body, and a wire extending from a proximal end portion to a distal end portion of the guide section, being returned at the distal end portion of the guide section, and extends toward the proximal end portion of the guide section to be connected to the actuation section.
