University of Rhode Island Board of Trustees;Yale University
发明人:
Yana K. Reshetnyak,David Wolfsohn,Anna Moshnikova,Oleg A. Andreev,Donald M. Engelman
申请号：
US16818527
公开号：
US20200323882A1
申请日:
2020.03.13
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention features a composition comprising a corticosteroid and a pHLIP® peptide. pHLIP® peptides target corticosteroids to cell surface acidity in inflamed and fibrotic tissues, where they translocate corticosteroids across plasma membranes into the cytoplasms of cells, thereby suppressing inflammation in the targeted tissues while avoiding the side effects resulting from non-targeted administration.
