Paul A. Wender,Jonathan B. Rothbard,Lee Wright,Erik L. Kreider,Christopher J. VanDeusen
申请号：
US13248783
公开号：
US20120225826A1
申请日:
2011.09.29
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides compositions and methods for enhancing transport of biologically active compounds across biological membranes and across and into animal epithelial or endothelial tissues. The composition includes a biologically active agent and a transport moiety. The transport moiety includes a structure selected from the group consisting of (ZYZ)nZ, (ZY)nZ, (ZYY)nZ and (ZYYY)nZ. Subunit “Z” is L-arginine or D-arginine, and subunit “Y” is an amino acid that does not comprise an amidino or guanidino moiety. Subscript “n” is an integer ranging from 2 to 10. The method for enhancing transport involves the administration of the aforementioned composition.
