A method of calibrating a mechanical model of behavior and movement of an interventional radiology table by moving the table over at least one degree of freedom, acquiring at least one set of images corresponding to different positions of the table and C-arm, obtaining at least one set of images of a test object from different positions, using the images of the test object to determine parameters of the mechanical model of table behavior and movement, and combining these parameters with data given by table movement sensors so as to deduce the true relative positions of the table with respect to the medical imaging system.