Hans Kaspar Binz,Patrik Forrer,Michael Tobias Stumpp
申请号:
US15015902
公开号:
US09849158B2
申请日:
2016.02.04
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a polyethylene glycol moiety and a binding domain, which inhibits VEGF-Axxx binding to VEGFR-2. Examples of such recombinant binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity, and a polyethylene glycol moiety. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.