REPUBLIC OF KOREA (MANAGEMENT: MINISTRY OF AGRICULTURE; FOOD AND RURAL AFFAIRS)
发明人:
AN, Dong Jun,안동준,KIM, Byoung Han,김병한,IM, Sung In,임성인,CHOE, Se Eun,최세은,CHO, In Soo,조인수,JEOUNG, Hye Young,정혜영,SONG, Jae Young,송재영,KIM, Jae Jo,김재조,HAN, Gyoo Ha,한규하,HYUN, Bang Hun,현방훈
申请号：
KRKR2016/015504
公开号：
WO2017/116177A3
申请日:
2016.12.29
申请国别(地区):
WO
年份:
2018
代理人:
摘要：
The present invention relates to an attenuated swine fever virus live marker vaccine strain and a vaccine composition for oral administration using same and, more particularly, to: an attenuated swine fever virus live marker vaccine strain (CSFV BErns attenuated C-P50) obtained by alternately and continuously culturing the conventional swine fever virus vaccine strain Flc-LOM-BErns between cells a vaccine composition for oral administration comprising same and a method for serologically differentiating between swine infected outdoors with swine fever virus and swine inoculated with the attenuated swine fever virus live marker vaccine strain. The safety of the attenuated swine fever virus live marker vaccine strain, CSFV BErns attenuated C-P50, according to the present invention has been enhanced by mitigating side effects, such as abortions/stillbirths in pregnant sows, which are problems of conventional swine fever virus vaccine strains. Also, the vaccine composition for oral administration according to the present invention can be made into bait dosage forms and easily consumed by swine and thus has solved the problem of conventional swine fever virus vaccines being used only as injections and thus difficult to be administered to fierce farmed wild boars and black pigs. Further, the serological differentiation method according to the present invention enables differentiation of the antigens and antibodies of swine infected outdoors with swine fever virus and swine inoculated with the attenuated swine fever virus live marker vaccine strain, CSFV BErns attenuated C-P50, and thus has the excellent effect of differentiating infected from vaccinated animals (DIVA).La présente invention concerne une souche pour vaccin marqueur de virus vivant atténué de la peste porcine et une composition de vaccin pour administration orale lutilisant et, plus particulièrement: une souche pour vaccin marqueur de virus vivant atténué de la peste porcine (CSFV BErns atténué C-P50) obtenue
