Kenya Honda,Bernat Olle,Koji Atarashi,Takeshi Tanoue,Hiroshi Ohno,Shinji Fukuda,Koji Hase
申请号：
US15680629
公开号：
US10130695B2
申请日:
2017.08.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Compositions consisting of bioactive molecules derived from the microbiota of a mammal are provided herein. When administered orally with a colonic delivery system, the compositions are useful for the prophylaxis and treatment of diseases, in particular inflammatory, autoimmune and infectious diseases. The compositions comprise combinations of small molecules and bacterial antigens formulated in colonic delivery systems. Use of the compositions results in any or all of: induction of immune tolerance； strengthening of the gut mucosal barrier integrity； reduction of inflammation； and amelioration of a disease state caused by inflammation, an autoimmune reaction or an infectious agent.
