A system and method are provided for change detection in medical images. A difference image representing intensity differences between a first medical image and a second medical image is generated. A mixture model is fitted to an intensity distribution of the difference image to identify a plurality of probability distributions which collectively model the intensity distribution. A plurality of intensity ranges is determined as a function of the plurality of probability distributions. Image data of the difference image is labeled by determining into which of the plurality of intensity ranges said labeled image data falls. Accordingly, more accurate change detection is obtained than known systems and method.
