PROBLEM TO BE SOLVED: To provide orally disintegrating tablets for administering a probiotic substance as an activated mucosal adhesive composition for administering an active substance to the oral cavity and as a corresponding mucosal adhesive dosage form, and to provide production methods thereof.SOLUTION: An orally disintegrating tablet has (a) an activated mucosal adhesive composition having a mucosal adhesive polymer selected from polyacrylic acid, hypromellose, and chitosan, and probiotics or a solid active agent which is a derivative thereof； and (b) an excipient having at least one disintegrant, being produced by mixing and compressing (a) and (b). A method comprises mixing a solid active agent and a mucosal adhesive polymer with a binder solution, producing granules from a mixture, as well as drying and screening to produce activated adhesive granules.SELECTED DRAWING: Figure 1【課題】口腔に活性物質を投与する活性化された粘膜付着性組成物及び対応する粘膜付着性剤形でプロバイオティクス物質を投与するための口腔内崩壊錠及びその製造方法の提供。【解決手段】（ａ）ポリアクリル酸、ヒプロメース又はキトサンから選択される粘膜付着性ポリマーと、プロバイオティクス又はその誘導体である固形活性剤とを有する活性化された粘膜付着性組成物と、（ｂ）少なくとも１つの崩壊剤を有する賦形剤とを有し、（ａ）及び（ｂ）を混合及び圧縮して生成される口腔内崩壊錠。固形活性剤及び粘膜付着性ポリマーをバインダ溶液で混合し、混合物から顆粒を生成し、乾燥、ふるい分けして、活性化された粘着性顆粒剤を生成する方法。【選択図】図１
