Component (A): L- arginine or that salt, component (B): Caffeine or that salt, component (C): Vitamin C or that derivative, vitamin E or that derivative, and folic acid or 1 kinds or more which are selected, containing three components from the group which consists of that derivative, the medicine composition and the composition for the eating and drinking item which become show the effect of the L- arginine low regarding the dosage. Therefore, as the medicine, and the eating and drinking item, arteriosclerosis, blood vessel expansion and the high fat blood symptom, the change of life obstacle, diabetes and the heart attack, the hypertension, happening incompletion and the thrombus symptom, immunity incompletion, the dementia symptom and the pregnancy poisoning symptom, prevention and improvement of disease of 1 kinds or more which are selected and/or it is possible from the group which consists of breath incompletion and the hemorrhoids to use for ideal for one for remedy.成分(A):L-アルギニン又はその塩、成分(B):カフェイン又はその塩、成分(C):ビタミンC又はその誘導体、ビタミンE又はその誘導体、及び、葉酸又はその誘導体からなる群より選択される1種以上、の三成分を含有してなる医薬組成物及び飲食品用組成物は、低薬量においてもL-アルギニンの効果を発揮する。したがって、薬剤、及び飲食品として、動脈硬化、血管拡張、高脂血症、更年期障害、糖尿病、狭心症、高血圧、勃起不全、血栓症、免疫不全、痴呆症、妊娠中毒症、呼吸不全、痔疾からなる群より選択される1種以上の疾病の予防、改善及び/又は治療用に好適に用いることができる。
