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COMPOSE DE PYRAZOLE
专利权人:
DAINIPPON SUMITOMO PHARMA CO.; LTD.
发明人:
SASAKI, IZUMI,TOYODA, TOMOHIRO,YOSHINAGA, HIDEFUMI,NATSUTANI, ITARU,TAKAHASHI, YOKO
申请号:
CA2805219
公开号:
CA2805219A1
申请日:
2011.07.14
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
The present invention relates to a novel serotonin reuptake inhibitor having 5-HT2C antagonism, particularly, also having 5-HT2C inverse agonism, which contains a compound represented by formula (1) or a pharmaceutically acceptable salt thereof and has antidepressive activity and anxiolytic activity. In formula (1), R1, R2, R3, and R4 each independently represent a hydrogen atom, a C1-6 alkyl group, or the like; R5 represents a C4-7 alkyl group or -(CR8R9)r-E; R6, R7, R8, and R9 each independently represent a hydrogen atom, a fluorine atom, or a C1-6 alkyl group; A represents a C6-10 aryl group, a heteroaryl group, or the like; r represents 1, 2, 3, or 4; E represents a C3-8 cycloalkyl group, a C6-10 aryl group, or the like; L represents an oxygen atom, a sulfur atom, or -NR10-; n represents 1, 2, or 3; R10 represents a hydrogen atom, a C1-6 alkyl group, or the like; and X represents a hydrogen atom, a halogen atom, or the like.
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