Ranney, Jesse,Horn-Ranney, Elaine,Khoshakhlagh, Parastoo,Moore, Michael
申请号：
AU2017200796
公开号：
AU2017200796A1
申请日:
2017.02.06
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2017200796A120170223.pdf#####ABSTRACT OF THE DISCLOSURE Otologic materials and methods are provided. For example, a cell-adhesive, biodegradable hydrogel scaffold loaded with time-released drugs for repairing chronic tympanic membrane perforations is disclosed, methods of making same and administering same are provided. This 5 hydrogel may promote vascular in-growth and epithelial cell growth of the tympanic membrane with the purpose of closing the perforation and providing a barrier between the external and middle ear. The hydrogel is initially a liquid polymer that only gels upon exposure to specific conditions, such as exposure to light. This scaffold may simultaneously induce repair of the tympanic membrane while preventing or alleviating middle ear infection, thus filling a void in current tympanic membrane 10 perforation therapies.
