The present disclosure provides methods and systems for neurostimulation at the tract of Lissauer. A neurostimulation system includes an implantable pulse generator, and a lead assembly electrically coupled to the implantable pulse generator, the lead assembly including a plurality of sensing electrodes configured to sense pain signals at a tract of Lissauer of a subject, and a plurality of stimulating electrodes configured to apply stimulation to a dorsal column of the subject based on the sensed pain signals.
