Various manners are disclosed in which neurostimulation can be programmed to provide stimulation pulses designed to alter the level of synchronization in a target neural tissue, as is useful in Deep Brain Stimulation (DBS) therapy for example. Stimulation pulses are issued in pulse packets, with one or more variations added within or between pulse packets, such as variations in pulse width, amplitude, frequency, or shape. Such variations afford greater ability to differentially recruit sub-populations of neural tissue in both space and time. Such pulse packets may be issued from one or more electrodes, which pulse packets may or may not overlap in time.
