A prefilled syringe consists of a syringe cylinder (2) which is open at one axial side and is closed by a plunger and which has a Luer lock connection (4) on the other axial side, said lock being molded on an end wall (3) which closes the syringe cylinder (2). The syringe comprises a flowable medium (8) which is filled into the syringe cylinder (2), a soft- elastic stopper (9) which closes at least the Luer (5), and a tamper- evident closure (15) which surrounds the outside of the stopper (9) and which has a predetermined breaking point. The syringe cylinder (2) the end wall (3) and the Luer lock connection (4) are formed as a single piece in the form of a transparent injection- molded plastic part. The tamper- evident closure (15) consists of the same or a similar plastic as the syringe cylinder (2) and is welded to the end wall (3) of the syringe cylinder (2). The welding connection forms the predetermined breaking point , and the stopper (9) is integrated into the tamper -evident closure (15).
