Provided are a therapeutic agent and a therapeutic method for canine atopic dermatitis. The therapeutic method for atopic dermatitis in animals and the therapeutic drug for atopic dermatitis in animals are characterized in that 2.5-10.0 mg/kg of roxithromycin and/or a pharmaceutically acceptable salt thereof and 12.5-50.0 mg/kg of pentoxifylline and/or a pharmaceutically acceptable salt thereof are to be simultaneously administered along with meals at 12-hour intervals for 60 days. The present invention provides an advantageous effect of preventing recurrence of symptoms for at least 30 days even after cessation of drug administration.
