#$%^&*AU2016204747A120160728.pdf#####Abstract This invention is directed to the treatment of cancer, particularly castration-resistant prostate cancer and osteoblastic bone metastases, with a dual inhibitor of MET and VEGF. 39WO 2012/044572 PCT/US201 1/053233 3/3 Patient 3 Baseline Week 6 Week 12 B 200 1 a AP 20 S16,20. S 0 00 1 4M 20 0 -2 0 24 8 10 12 14 16 18 20 Weeks on Study HIG. 3 96959513