PROBLEM TO BE SOLVED: To provide an artificial stone calcified tissue recovering lost function and shape of hard tissues of living matter, having 3 requirements of biocompatibility, bioadhesiveness and mechanical tolerance and approximating the hard tissues, an artificial stone calcified prosthetic material for generating the artificial stone calcified tissue, and a manufacturing method of the artificial stone calcified tissue by using the artificial stone calcified prosthetic material.SOLUTION: There is provided an artificial stone calcified tissue constituted by hydroxyapatite and collagen. There is provided an artificial stone calcified tissue, where an artificial stone calcified prosthetic material for manufacturing the artificial stone calcified tissue is constituted by an inorganic material by mixing an inorganic material which is a solution of collagen or gelatin and DCPA powder and TTCP powder. There is further provided a manufacturing method of the artificial stone calcified tissue including mixing an organic material and the inorganic material, then filling them into dentin or ossein at same time or separately and reacting them in the presence of water or an extracellular fluid. There is provided an artificial stone calcified prosthetic material constituted by an organic material which is a solution of gelatin and an inorganic material by mixing calcium hydrogen phosphate powder and tetracalcium phosphate powder.SELECTED DRAWING: None【課題】生体の硬組織の失われた機能と形態を回復し、生体親和性、生体接着性及び力学耐性の３要件を備え、硬組織に近似した人工石灰化組織及びその人工石灰化組織を生成する為の人工石灰化補填材料、並びに、その人工石灰化補填材料を用いた人工石灰化組織の製造方法の提供。【解決手段】ハイドロキシアパタイトとコラーゲンとから構成される人工石灰化組織。人工石灰化組織を製造する為の人工石灰化補填材料が、コラーゲン又はゼラチンの水溶液である有機系材料と、ＤＣＰＡ粉末及びＴＴＣＰ粉末を混合した無機系材料とから構成される、人工石灰化組織。更に、有機系材料と無機系材料を、混合した後、同時に又は別々に、歯質内又は骨質内に填入し、水又は細胞外液の存在下で反応させる人工石灰化組織の製造方法。ゼラチンの水溶液である有機系材料と燐酸水素カルシウム粉末及び燐酸四カルシウム粉末を混合した無機材料と、から構成される人工石灰化補填材料。【選択図】なし
