PROBLEM TO BE SOLVED: To provide an isosorbide solid preparation prepared by forming a pharmaceutical composition which contains highly-hygroscopic and easily-agglomerated crystalline isosorbide into the preparation which is stably maintained and easily administered.SOLUTION: This isosorbide preparation is prepared by packing the pharmaceutical composition which contains the crystalline isosorbide having a granular shape and a water content of &le 0.5% and a lubricant into an aluminum-containing packaging material not permeated with moisture.COPYRIGHT: (C)2006,JPO&NCIPI【課題】イソソルビドの固形剤の提供。【解決手段】顆粒状で含水率が0.5%以下の結晶イソソルビドと滑沢剤を含有する医薬組成物が水分を透過しないアルミニウムを含む包装材料で包装されていることを特徴とするイソソルビド製剤。【効果】高吸湿性かつ易固結性の結晶イソソルビドを含有してなる医薬組成物を、安定に維持し,服用し易い製剤とすることができる。
