Sarah Lee POGUE,David Scofiled WILSON, JR.,Tetsuya TAURA
申请号：
US16317077
公开号：
US20200010544A1
申请日:
2017.07.19
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides a combination therapy for treating a tumor in a subject. The combination comprises two elements. The first is a polypeptide construct comprising an attenuated Type 1 interferon (IFN) linked to an antibody which binds to a cell surface-associated antigen expressed on the tumour cell and comprising a functional Fc region. The second is a CD47 antagonist which inhibits the interaction CD47 with the SIRPα receptor.
