JOEL D. BUMGARDNER,CHAOXI WU,HENGJIE SU,TOMOKO FUJIWARA,DANIEL G. ABEBE,KWEI-YU LIU,GREGORY MCGRAW,CARLOS LEE BUMGARDNER
申请号：
US15120990
公开号：
US20160367722A1
申请日:
2015.02.27
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention includes chitosan nanofibers having enhanced structural integrity, compositions comprising such chitosan nanofibers, and related methods of use. In a particular aspect, electrospun chitosan nanofibers can be reversibly acylated to enhance structural integrity and promote healing and the formation of tissues in a subject. In another aspect, electrospun chitosan nanofibers comprising at least a portion of the amino groups protected, such as through N-tert-butoxycarbonyl groups, demonstrate enhanced structural integrity and promote healing and the formation of tissues in a subject. The invention also includes compositions and methods for producing a modified chitosan material having anti-inflammatory and pro-healing characteristics and methods of using the modified chitosan materials in a film, a gel, a membrane, microfibers, nanofibers, nano- or micro-particles/spheres and/or sponges. In some aspects, microspheres and methods of producing microspheres comprising modified chitosan are included.
