A source delivery surgical staple device delivers a source/seed to a staple margin. The surgical staple delivery device includes a main staple body segment hingedly attached to a second body segment. Each of the segments is appointed for engagement to dispense the sources/seeds for the treatment of microscopic disease to a surgical margin. The device also includes a cartridge removably attached and snapped onto the main staple body segment. The cartridge has a source/seed/brachy staple line forming a brachy or radioactive seeds and/or chemotherapy agent dosage source. The radioactive seeds have a radioactive and/or chemotherapy source supported by leg portions that are manipulated during insert for fastening the radioactive staples to tissue at an incision margin. A hybrid of chemotherapy agent and radiation is delivered directly into the surgical margin and different dosage can be loaded in the cartridge.
