A method and system for acquiring and analyzing multiple image data loops comprising: receiving a set of ultrasound data, characterizing a tissue, collected over a first collection loop and a second collection loop； determining a tissue parameter distribution within the tissue based on the set of ultrasound data and multi-dimension speckle tracking； receiving identification of at least one region of interest represented in the set of ultrasound data in the first collection loop and the second collection loop； measuring a comparative characteristic, in the region of interest, between the first collection loop and the second collection loop； and rendering at least one of the comparative characteristic and the tissue parameter distribution. The system comprises a processor, an analysis engine, and a user interface, and may further comprise an ultrasound scanner. The system is preferably configured to perform the method.
