This invention provides superactive analogs of FSH demonstrating enhancedbioactivity both in vitro and in vivo as compared to wild type FSH. Inparticular, the analogs of the invention demonstrate at least a ten foldincrease in potency or at least a ten percent increase in maximal efficacy ascompared to wild type protein. The analogs are particularly useful fortreating subjects showing low FSH receptor expression or poor FSH receptorresponsiveness, and for the treatment of any condition associated withglycoprotein hormone activity.
