A use of manufacturing a pharmaceutical composition for cooperative use of Metformin and sodium butyrate to treat a cancer patient with K-ras mutation is disclosed. When administering the pharmaceutical composition to the cancer patient, Metformin and sodium butyrate offer cooperatively therapeutic efficacy. The present invention also discloses a pharmaceutical composition and a pharmaceutical kit containing the two aforementioned. The application of the use, the pharmaceutical composition and the pharmaceutical kit of the present invention is advantageous for improving the treatment effect to cancer patients with K-ras mutation.一種二甲雙胍與丁酸鈉用於製造治療一具有K-ras基因突變之癌症患者的醫藥組合物之用途,且當投以該醫藥組合物予該癌症患者,該二甲雙胍與該丁酸鈉提供合併治療之效果。本發明另揭露一種含有上述兩者的醫藥組合物及醫藥套組。利用本發明之用途、醫藥組合物與醫藥套組,可改善對於具有K-ras基因突變之癌症患者的療效。
