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CRYSTALLINE FORM OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL) PYRIDIN-5-YL)-3-FLUOROPHENYL)-5-HYDROXYMETHYL OXAZOLIDIN-2-ONE DIHYDROGEN PHOSPHATE
专利权人:
发明人:
REICHENBACHER KATHARINA,DUGUID ROBERT J,SIMSON JACQUELINE A,PHILLIPSON DOUGLAS
申请号:
IN6223/CHENP/2011
公开号:
IN2011CN06223A
申请日:
2011.08.29
申请国别(地区):
IN
年份:
2012
代理人:
摘要:
A crystalline form of crystalline (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate, methods of making the crystalline form and pharmaceutical compositions comprising the crystalline form are useful antibiotics. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such as Bacteroides and Clostridia, and acid-resistant microorganisms such as Mycobacterium tuberculosis and Mycobacterium avium. Accordingly, the compositions comprising the crystalline form may be used in antibiotics.
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