Multilayer beads for pharmaceutical use having a drug-in-polymer layer are disclosed. The disclosed multilayer beads for pharmaceutical use have (a) a core particle； (b) an optional barrier layer coated on the surface of the core particle； (c) a drug-in-polymer layer coated on the surface of the core or the barrier layer, (d) an optional sealant layer coated on the surface of the drug-in-polymer layer； and (e) optionally one or more outer layers external to the drug-in-polymer layer or the sealant layer. The drug-in-polymer layer consists essentially of (i) a drug selected from the group consisting of a 15-keto prostaglandin drug, a 13,14-dihydro prostaglandin drug, and a 13,14-dihydro-15-keto prostaglandin drug； and (ii) a polymer selected from the group consisting of polyvinylpyrrolidone, vinylpyrrolidone-vinylacetate copolymer or a mixture thereof. The drug-in-polymer layer may be solid dispersion of the drug in the polymer. Pharmaceutical compositions comprising a plurality of multilayer beads and a pharmaceutically acceptable excipient and methods of treating a gastrointestinal disorder are also disclosed.揭示了用於藥學用途之具有一聚合物包藥層的多層珠粒。所揭示用於藥學用途之多層珠粒具有(a)一核心顆粒；(b)一任擇的屏障層，其塗覆在該核心顆粒的表面上；(c)一聚合物包藥層，其塗覆在該核心或該屏障層的表面上(d)一任擇的密封層，其塗覆在該聚合物包藥層的表面上；以及(e)任擇地一或多個外層，其在該聚合物包藥層或該密封層的外面。該聚合物包藥層基本上由下列構成：(i)一藥，選自由下列構成之群組：15-酮基前列腺素藥、13,14-二氫前列腺素藥、和13,14-二氫-15-酮基前列腺素藥；以及(ii)一聚合物，選自由下列構成之群組：聚乙烯吡咯烷酮、乙烯基吡咯烷酮-乙酸乙烯酯共聚物或其等之混合物。該聚合物包藥層可為該藥在該聚合物中的固體分散物。亦揭示了包含複數個多層珠粒和一藥學上可接受的賦形劑的藥學組成物以及治療腸胃病症的方法。
