COMPOSITION FOR ALLEVIATING NEPHROTOXICITY CAUSED BY IMMUNOSUPPRESSIVE DRUG, COMPRISING METFORMIN, AND COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASE, COMPRISING THE SAME
Mi La CHO,Chul Woo YANG,Jong Young CHOI,Sung Hwan PARK,Min Jung PARK,Seon Yeong LEE,Joo Yeon JHUN,Eun Jung LEE,Jae Kyung KIM,Eun Kyung KIM,Sun Woo LIM
申请号：
US15537486
公开号：
US20170348256A1
申请日:
2015.12.18
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided is a composition for alleviating nephrotoxicity caused by an immunosuppressive drug, including metformin, and a composition for preventing or treating an immune disease, including the same. Further, the composition provided can be useful in improving a treatment effect on diseases requiring immunosuppression by effectively alleviating a decline in renal function caused due to side effects of conventional immunosuppressive drugs, and can also be useful in preventing or treating organ transplant rejection, autoimmune diseases, inflammatory diseases and the like since various methods of co-administering a conventional immunosuppressive drug and metformin are suggested to reduce nephrotoxic side effects of conventional immunosuppressive drugs and maximize immunosuppressive or immunomodulatory effects.
