Joseph J. Buggy;Shanthi Adimoolam;Richard Miller;Darren Magda
发明人:
Shanthi Adimoolam,Joseph J. Buggy,Darren Magda,Richard Miller
申请号：
US11952985
公开号：
US09408816B2
申请日:
2007.12.07
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided herein are methods for using at least one histone deacetylase inhibitor to decrease cellular DNA repair activity, methods for monitoring the decrease of cellular DNA repair activity using at least one biomarker, methods of treating cancer by using at least one histone deacetylase inhibitor to decrease cellular DNA repair activity in combination therapy, methods of combination therapy where at least one histone deacetylase inhibitor interferes with a DNA repairing mechanism involving RAD51, methods for predicting a induction time period between a first administration of at least one histone deacetylase inhibitor and a second administration of at least one other therapeutic treatment, and pharmaceutical compositions for combination therapy.
