A pharmaceutical dosage system comprising (a) an effective amount of one or more of (i) Doxylamine and (ii) a pharmaceutically acceptable salt thereof； (b) an effective amount of one or more of (i) a Pyridoxine compound of formula II, in which formula II is represented in the Abstract Drawing, wherein R1 is a hydroxyl or phosphate group； and R2 is CH2OH, CHO, or CH2NH2； (ii) a pharmaceutically acceptable ester of (i)； and (iii) a pharmaceutically acceptable salt of any of (i)-(ii)； and (c) an effective amount of one or more of riboflavin, riboflavin-5-phosphate, flavin adenine dinucleotide, or a pharmaceutically acceptable salt thereof. The system exhibits an improved pharmacokinetic profile relative to the current Diclectin®/Diclegis® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP).
