Modulators of hec1 activity and methods therefor

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专利权人:

TAIVEX THERAPEUTICS INC.

发明人:

LAU JOHNSON,HUANG JIANN-JYH

申请号：

NZ60212111

公开号：

NZ602121A

申请日:

2011.03.15

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

4-Phenyl-1,3-Thiazole Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. The compounds disrupt Nck2/Hecl binding and are therefore useful as chemotherapeutic agent for neoplastic diseases mediated by microtuble degradation or formation. Compounds disclosed include: N-(4-(2,4,6-Trimethylpyridin-3-yl)thiazol-2-yl)picolinamide, N-(4-(4-Ethoxy-2,6-dimethylphenyl)thiazol-2-isonicotinamide, 4-Cyano-N-(4-(4-hydroxy-2-methylphenyi)thiazol-2-yl)benzamide and N-(4-(4-Isobutoxy-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/