INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
Ching-Pin CHANG,Jin YANG
申请号：
US16777641
公开号：
US20200164025A1
申请日:
2020.01.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Methods are disclosed herein for administering a FoxM1 inhibitor for preventing, treating, and/or reducing cardiac hypertrophy and/or cardiac failure. Particularly, the methods are directed to the use of a FoxM1 inhibitor to block the function of FoxM1-Brg1 complex, thereby reversing the ACE/ACE2 expression ratio such to protect the heart from hypertrophy and failure.
