NATIONAL CHENG KUNG UNIVERSITY;NATIONAL TAIWAN UNIVERSITY
发明人:
CHUANG, WOEI JER,庄伟哲,莊偉哲,FU, WEN MEI,符文美
申请号：
TW099123673
公开号：
TWI557224B
申请日:
2010.07.19
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The invention generally relates to fusion proteins comprising a rhodostomin variant having an RGD motif variant 48ARLDDL53, wherein the rhodostomin variant is conjugated with a variant of Human Serum Albumin (HSA). The invention also relates to the use of these fusion proteins for treatment and prevention of αvβ3 integrin-associated diseases.本發明一般係關於包含具有RGD基元變體48ARLDDL53之馬來亞蝮蛇蛇毒蛋白(rhodostomin)變體的融合蛋白，其中該馬來亞蝮蛇蛇毒蛋白變體與人類血清白蛋白(HSA)變體結合。本發明亦係關於該等融合蛋白用於治療及預防與αvβ3整合蛋白相關之疾病的用途。
